IMMUNOLOGY PROGRAMME COURSE DESCRIPTION

Code	Name of the Course Unit	Semester	In-Class Hours (T+P)	Credit	ECTS Credit
PER346	IMMUNOLOGY	6	2	2	4

GENERAL INFORMATION
Language of Instruction :	Turkish
Level of the Course Unit :	, TYY: + , EQF-LLL: , QF-EHEA:
Type of the Course :	Compulsory
Mode of Delivery of the Course Unit	-
Coordinator of the Course Unit
Instructor(s) of the Course Unit
Course Prerequisite	No

OBJECTIVES AND CONTENTS
Objectives of the Course Unit:	It is aimed for students to recognize the basic components of the immune system and to interpret the immune response during perfusion processes.
Contents of the Course Unit:	Resistance mechanisms and immune response system

KEY LEARNING OUTCOMES OF THE COURSE UNIT (On successful completion of this course unit, students/learners will or will be able to)
Explain the basic concepts in immunology.
Explain how immune response is given against microbes.
Relate immunity and immunotherapy in cancer patients.
Compare the transfusion and transplantation immunology.
Explain immunodeficiency diseases.

WEEKLY COURSE CONTENTS AND STUDY MATERIALS FOR PRELIMINARY & FURTHER STUDY
Week	Preparatory	Topics(Subjects)	Method

SOURCE MATERIALS & RECOMMENDED READING
Gravlee, G. P., Davis, R. F., Hammon, J., & Kussman, B. (2015). Cardiopulmonary bypass and mechanical support: Principles and practice (4th ed.). Lippincott Williams & Wilkins.
Hatami, S., Panconesi, R., Knijff, L., Langford, G., Fodor, M., & editors. (2022). Immunology of machine‑perfused organs and tissues. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.1104268
Hullegie‑Peelen, D. M., Tejeda‑Mora, H., Hesselink, D. A., et al. (2024). Tissue‑resident lymphocytes are released during hypothermic and normothermic machine perfusion of donor kidneys. Transplantation, 108(7), 1551–1557. https://doi.org/10.1097/TP.0000000000004936
Knijff, L., et al. (2022). Impact of hypothermic oxygenated machine perfusion on immune cell clearance and graft function. Journal of Clinical Medicine, 14(1), 127. https://doi.org/10.3390/jcm14010127
Lee, A. C. H., et al. (2022). The effect of normothermic machine perfusion on the immune profile of donor liver. Frontiers in Immunology, 13, 788935. https://doi.org/10.3389/fimmu.2022.788935
Stone, J. P., Critchley, W. R., Major, T., et al. (2016). Normothermic perfusion induces donor‑derived leukocyte mobilization and removal prior to renal transplantation. Kidney International Reports, 1, 230–239. https://doi.org/10.1016/j.ekir.2016.02.006

ASSESSMENT
Assessment & Grading of In-Term Activities	Number of Activities	Degree of Contribution (%)	Description	Examination Method
Mid-Term Exam	1	50		Optical (Test) Exam
Final Exam	1	50		Optical (Test) Exam
TOTAL	2	100

Level of Contribution
0	1	2	3	4	5

KNOWLEDGE
Theoretical
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	Students can evaluate and apply the knowledge that is gained from lecture notes, application tools and visual and objective sources that support basic theoretical and practical courses,				3
2	They can monitor patient follow-up and, if necessary, they can apply appropriate drugs to the cardiopulmonary bypass system under the supervision of specialist doctors and anesthesiologist			2

KNOWLEDGE
Factual
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	They can make installation and applications on Heart-lung machines and other equipment				3
2	They can make the necessary applications in situations requiring first aid.			2

SKILLS
Cognitive
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	Being well-aware of their individual responsibilities within the team, they can analyze the data related to patients and produces results.					4

SKILLS
Practical
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	They can make all the practices relevant to perfusion in accordance with perfusion techniques				3

OCCUPATIONAL
Autonomy & Responsibility
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	Being well-aware of their individual responsibilities within the team, they can fulfill their tasks completely.						5

OCCUPATIONAL
Learning to Learn
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	They can update their Perfusion-related knowledge, skills and competencies with the self-awareness of a lifelong learning and move further in their personal and professional fields.					4

OCCUPATIONAL
Communication & Social
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	They can communicate effectively, informative and ethically with patients, relatives and with other health professionals.						5

OCCUPATIONAL
Occupational and/or Vocational
	Programme Learning Outcomes	Level of Contribution
		0	1	2	3	4	5
1	They can make the preparation and application of the Heart-Lung machine and other auxiliary equipment			2
2	Compatible with Team work, individual responsibility can be fulfilled.						5

WORKLOAD & ECTS CREDITS OF THE COURSE UNIT
Workload for Learning & Teaching Activities
Type of the Learning Activites	Learning Activities (# of week)	Duration (hours, h)	Workload (h)
Lecture & In-Class Activities	14	2	28
Preliminary & Further Study	14	1	14
Land Surveying	0	0	0
Group Work	0	0	0
Laboratory	0	0	0
Reading	0	0	0
Assignment (Homework)	0	0	0
Project Work	0	0	0
Seminar	0	0	0
Internship	0	0	0
Technical Visit	0	0	0
Web Based Learning	0	0	0
Implementation/Application/Practice	0	0	0
Practice at a workplace	0	0	0
Occupational Activity	0	0	0
Social Activity	0	0	0
Thesis Work	0	0	0
Field Study	0	0	0
Report Writing	0	0	0
Final Exam	1	1	1
Preparation for the Final Exam	10	4	40
Mid-Term Exam	1	1	1
Preparation for the Mid-Term Exam	1	1	1
Short Exam	5	3	15
Preparation for the Short Exam	0	0	0
TOTAL	46	0	100